ABCG subfamily in GtoPdb v.2023.1

This family of 'half-transporters' act as homo- or heterodimers; particularly ABCG5 and ABCG8 are thought to be obligate heterodimers. The ABCG5/ABCG heterodimer sterol transporter structure has been determined [6], suggesting an extensive intracellular nucleotide binding domain linked the transmembrane domains by a fold in primary sequence. functional ABCG2 appears homodimer with structural similarities ABCG5/ABCG8 [10, 1].